Cytauxzoonosis
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The Fatal Tick-Transmitted Disease Continues to Spread

Cytauxzoonosis is caused by the protozoan parasite Cytauxzoon felis, a single-celled organism that is transmitted to domestic cats through the bite of an infected tick. Ticks feed on infected bobcats, the natural hosts of this parasite, and ingest the organisms which multiply within the tick. The organism is then spread to domestic cats when they are bitten by an infected tick. Once inside the domestic cat, cytauxzoon organisms multiply in the tissues. These infected cells occlude vessels of the liver, spleen, lungs, and lymph nodes. Eventually these infected cells rupture and release the organisms into the blood stream, where they infect the red blood cells.

The clinical course of the disease is rapid with most cats showing symptoms within five to seven days of infection. Typical clinical manifestations include signs of depression, lethargy, anorexia, fever of 104˚F-106˚F, jaundice, and anemia. About 24 hours prior to death, the cat’s temperature will begin to decline to subnormal levels. Most cats rapidly succumb to the disease, often dying within one week of the initial onset of clinical signs.

Unfortunately, the initial clinical signs are nonspecific and can resemble many other common feline afflictions. Diagnostic testing is directed both toward confirming the infection and ruling out other diseases. A presumptive diagnosis of cytauxzoonosis is made based on clinical signs, risk factors, and laboratory test results. Definitive diagnosis is made by finding a form of the organism (piroplasms) in the blood or tissues of the patient.

Outdoor cats are most likely to acquire this disease, and cats most at risk are those with access to wooded areas, which provide appropriate habitat for both bobcats and ticks. The greatest seasonal risk of infection is spring and early summer when the tick vectors are most active.

Effective medical therapy remains elusive and although a few cats have survived, the vast majority of patients succumb to this disease. Following a confirmed diagnosis of Cytauxzoonosis, those owners who desire treatment for their cats are referred to Oklahoma State University’s Center for Veterinary Health Sciences. At OSU, experimental protocols have been developed with the hope of finding a treatment that will be successful.

Due to the high mortality rate of this disease, prevention is essential to the health of your cat. Following the steps outlined below can reduce the risk of your cat contracting this disease.

  • The first line of defense is to keep your cat indoors
  • Check all cats (even indoor pets) daily for ticks
  • Promptly remove any ticks found
  • Treatment with insecticides that kill ticks is essential. Fipronil (Frontline®) is a safe and effective product for killing ticks on cats. Unfortunately, it may take up to 48 hours for fipronil to kill a tick, and cytauxzoon can be transmitted to your cat during that period
Cytauxzoonosis is a dreadful disease, but by understanding the condition and taking the appropriate measures to prevent infection, you can keep your cat from becoming its next victim.
 

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